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This retrospective study explores Network Care, a health care discipline within the subluxation-based chiropractic model, using data from over 2,800 patients across 156 offices in the United States, Canada, Australia, and Puerto Rico. Patients reported significant positive changes across multiple health domains—including physical well-being, mental and emotional state, stress levels, and enjoyment of life—as well as overall quality of life. These improvements were evident as early as one to three months of care and continued to increase over time, with no apparent plateau. The findings suggest that Network Care is associated with progressive, long-term enhancements in self-reported wellness, supporting the need for continued longitudinal and neurophysiological research.